THAP12 and DDX58

Number of citations of the paper that reports this interaction (PubMedID 21910972)
1

Data Source:
BioGRID (pull down)

		THAP12	DDX58
Description		THAP domain containing 12	DExD/H-box helicase 58
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Ruffle Membrane Ribonucleoprotein Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity	Double-stranded DNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Signal Transduction Negative Regulation Of Cell Proliferation	Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Detection Of Virus Response To Virus Positive Regulation Of Gene Expression Viral Process Protein Deubiquitination Regulation Of Cell Migration Negative Regulation Of Type I Interferon Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Regulation Of Type III Interferon Production Positive Regulation Of Interferon-beta Secretion Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Interferon-alpha Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433)	Blood protein levels ( 30072576) Bone mineral density (spine) and age at menarche ( 26312577) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Inflammatory skin disease ( 25574825) Metabolite levels ( 23823483) Psoriasis ( 25903422 25574825 23143594) Psoriasis vulgaris ( 26626624) Red blood cell count ( 27863252)
Interacting Genes		8 interacting genes: DDX58 DNAJC3 EIF2AK2 EIF2S1 MAPKAPK3 STK4 TACC1 TP53	14 interacting genes: CYLD MAVS PRKCG RNF122 RNF135 THAP12 TRIM40 UBC UBE2D1 UBE2D2 UBE2D3 UBE2K USP15 USP3
Entrez ID		5612	23586
HPRD ID		09567	13131
Ensembl ID		ENSG00000137492	ENSG00000107201
Uniprot IDs		A0A140VJQ7 O43422	O95786
PDB IDs			2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG
Enriched GO Terms of Interacting Partners?
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