MAP2K2 and DUSP3

Number of citations of the paper that reports this interaction (PubMedID 10224087)
28

Data Source:
HPRD (in vitro, in vivo)

		MAP2K2	DUSP3
Description		mitogen-activated protein kinase kinase 2	dual specificity phosphatase 3
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Immunological Synapse Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Scaffold Protein Binding	Protein Tyrosine Phosphatase Activity Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Early Endosome To Late Endosome Transport	Inactivation Of MAPK Activity Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	ERKs are inactivated
Drugs		Bosutinib Trametinib
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Heel bone mineral density ( 30598549) Height ( 29782485) Pulse pressure ( 30224653)	Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) Metabolite levels ( 23823483) Triglycerides ( 25961943)
Interacting Genes		18 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 RAF1 RGS12 RIPOR2 ZNF207	14 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 NEUROD1 PDGFA STAT1 SYK ZAP70
Entrez ID		5605	1845
HPRD ID		03164	02553
Ensembl ID		ENSG00000126934	ENSG00000108861
Uniprot IDs		P36507	P51452
PDB IDs		1S9I 4H3Q	1J4X 1VHR 3F81
Enriched GO Terms of Interacting Partners?
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