PDGFC and PLAT

Number of citations of the paper that reports this interaction (PubMedID 22035541)
20

Data Source:
BioGRID (enzymatic study)

		PDGFC	PLAT
Description		platelet derived growth factor C	plasminogen activator, tissue type
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Apical Part Of Cell Collagen-containing Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity Growth Factor Receptor Binding	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding
	Biological Process	Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Central Nervous System Development Positive Regulation Of Cell Proliferation Animal Organ Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Positive Regulation Of MAP Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Embryonic Organ Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Bone Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Positive Regulation Of Cold-induced Thermogenesis	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Pathways			Signaling by PDGF Dissolution of Fibrin Clot
Drugs			Urokinase Aminocaproic Acid Ibuprofen Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Cognitive decline (age-related) ( 28078323) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Major depressive disorder ( 29317602) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 27863252) Plateletcrit ( 27863252) Prostate-specific antigen levels ( 28139693) Pulse pressure ( 30578418) Speech perception in dyslexia ( 19786962) Systolic blood pressure ( 30224653 30578418) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969)	Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)
Interacting Genes		5 interacting genes: PDGFRA PLAT PLAU ST14 SUMO1	36 interacting genes: ANXA2 APP BAG4 CALR CKAP4 CLEC3B CRABP1 CRTC1 DDHD2 EIF4EBP1 F10 FGA FN1 GML GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG PPP2CB PVR SART1 SERPINA5 SERPINE1 SERPING1 SERPINI1 SLC28A2 SPARC
Entrez ID		56034	5327
HPRD ID		10529	01419
Ensembl ID		ENSG00000145431	ENSG00000104368
Uniprot IDs		Q9NRA1	B4DN26 P00750
PDB IDs			1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?
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