NXT2 and CEP63

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NXT2	CEP63
Description		nuclear transport factor 2 like export factor 2	centrosomal protein 63
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Nuclear Pore Central Transport Channel Perinuclear Region Of Cytoplasm	Spindle Pole Centrosome Centriole Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Import Into Nucleus Nucleocytoplasmic Transport MRNA Transport	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Height ( 18391952) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		17 interacting genes: APP CCDC102B CEP63 GOLGA2 LNX1 NXF1 NXF2 NXF3 PKM PTPN3 REL SRPK1 SRPK2 SSBP3 STAT3 TRIM23 USP54	42 interacting genes: ALOX5 ARFIP2 ARNT2 CAMKK2 CCNI CDK1 CEP57L1 DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 HGS INTS6L KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNX4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TSHZ3 TXLNA USHBP1 ZCCHC10
Entrez ID		55916	80254
HPRD ID		02264	07826
Ensembl ID		ENSG00000101888	ENSG00000182923
Uniprot IDs		Q9NPJ8	Q96MT8
PDB IDs			6CSU 6CSV
Enriched GO Terms of Interacting Partners?
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