ACSS2 and UPF1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		ACSS2	UPF1
Description		acyl-CoA synthetase short chain family member 2	UPF1 RNA helicase and ATPase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Intracellular Membrane-bounded Organelle	Nuclear Chromosome, Telomeric Region Chromatin P-body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex
	Molecular Function	Acetate-CoA Ligase Activity ATP Binding AMP Binding Propionate-CoA Ligase Activity	Chromatin Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Telomeric DNA Binding
	Biological Process	Ethanol Oxidation Lipid Biosynthetic Process Acetate Biosynthetic Process Acetyl-CoA Biosynthetic Process From Acetate Propionate Biosynthetic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Cell Cycle Phase Transition Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Histone MRNA Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1
Pathways		Transcriptional activation of mitochondrial biogenesis Ethanol oxidation	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Adenosine monophosphate ATP
Diseases
GWAS		Bipolar disorder ( 31043756) Estimated glomerular filtration rate ( 31015462) Irritable mood ( 29500382) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		1 interacting genes: UPF1	36 interacting genes: ABHD16A ACRV1 ACSS2 AP1G1 ATR CNN1 CSNK2B DCP1A DCP2 DHPS DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG HIRA LDB1 LSM8 NADSYN1 NDRG1 NDUFB10 NOTCH3 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1
Entrez ID		55902	5976
HPRD ID		12053	03254
Ensembl ID		ENSG00000131069	ENSG00000005007
Uniprot IDs		Q4G0E8 Q6DKJ3 Q96FY7 Q9NR19	A0A024R7L5 A0A024R7L8 B3KY55 Q92900
PDB IDs			2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5
Enriched GO Terms of Interacting Partners?
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