BRK1 and NCKAP1

Number of citations of the paper that reports this interaction (PubMedID 8605018)
23

Data Source:
HPRD (in vivo, in vitro)

		BRK1	NCKAP1
Description		BRICK1 subunit of SCAR/WAVE actin nucleating complex	NCK associated protein 1
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome	Ruffle Cytosol Focal Adhesion Integral Component Of Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Rac GTPase Binding	Protein Binding Rac GTPase Binding
	Biological Process	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Positive Regulation Of Protein Complex Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Cell Morphogenesis Apoptotic Process Central Nervous System Development Positive Regulation Of Lamellipodium Assembly Viral Process Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810)	Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		7 interacting genes: BRAP CYFIP2 NCK1 NCKAP1 PFDN1 PIK3R3 WASF1	14 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 WASF1 WASF2 YWHAG
Entrez ID		55845	10787
HPRD ID		12818	05353
Ensembl ID		ENSG00000254999	ENSG00000061676
Uniprot IDs		Q8WUW1	Q9Y2A7
PDB IDs		3P8C 4N78	3P8C 4N78
Enriched GO Terms of Interacting Partners?
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