PPP2R2D and PTTG1

Number of citations of the paper that reports this interaction (PubMedID 16705156)
17

Data Source:
BioGRID (enzymatic study)

		PPP2R2D	PTTG1
Description		protein phosphatase 2 regulatory subunit Bdelta	PTTG1 regulator of sister chromatid separation, securin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding
	Biological Process	Mitotic Cell Cycle Exit From Mitosis Regulation Of Phosphoprotein Phosphatase Activity Cell Division Peptidyl-serine Dephosphorylation	DNA Repair Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Catabolic Process Homologous Chromosome Segregation Chromosome Organization Cell Division Negative Regulation Of Mitotic Sister Chromatid Separation
Pathways		MASTL Facilitates Mitotic Progression	APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Chronotype ( 30696823) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 30224653 30578418)	Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 21408207 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		3 interacting genes: DAPK1 PTTG1 SUPT5H	22 interacting genes: ANAPC11 ANAPC2 AURKA CAMK2A CDC20 CDC27 CDC34 CDK1 CRK CUL1 DNAJA1 FZR1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2N UBE4A XRCC6
Entrez ID		55844	9232
HPRD ID		15172	04998
Ensembl ID		ENSG00000175470	ENSG00000164611
Uniprot IDs		Q66LE6 Q6IN90	O95997 Q6IAL9
PDB IDs
Enriched GO Terms of Interacting Partners?
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