SELENOS and EIF2AK1

		SELENOS	EIF2AK1
Description		selenoprotein S	eukaryotic translation initiation factor 2 alpha kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex	Cytoplasm
	Molecular Function	Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding	Protein Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Heme Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis ER Overload Response Response To Glucose Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Acute Inflammatory Response Phagocytosis Negative Regulation Of Cell Proliferation Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of EIF2 Alpha Phosphorylation By Heme Macrophage Differentiation Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Negative Regulation Of Hemoglobin Biosynthetic Process Iron Ion Homeostasis Response To Iron Ion Starvation
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS			High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		24 interacting genes: BLZF1 CD180 CELF4 DERL1 EIF2AK1 ETV7 GTF2IRD1 KLHDC2 KPNB1 LIMK1 LINS1 LRRK1 MFHAS1 NCBP1 OR4F4 SAA1 SNRPA1 SRPK2 SYNM TARS3 TM2D3 TTC23 VCP ZBTB33	5 interacting genes: CDC37 EIF2S1 HSP90AA1 LIG4 SELENOS
Entrez ID		55829	27102
HPRD ID		12133	10684
Ensembl ID		ENSG00000131871	ENSG00000086232
Uniprot IDs		Q6GYA4 Q9BQE4	A0A024QZU1 Q9BQI3
PDB IDs		2Q2F 5KIU 5KIY 6DO4
Enriched GO Terms of Interacting Partners?
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