DCP1A and EDC3

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		DCP1A	EDC3
Description		decapping mRNA 1A	enhancer of mRNA decapping 3
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule	P-body Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Enzyme Regulator Activity Identical Protein Binding	MRNA Binding Protein Binding Identical Protein Binding Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Cytoplasmic MRNA Processing Body Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) Spontaneous preterm birth (preterm delivery) ( 25599974)	Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Craniofacial microsomia ( 26853712)
Interacting Genes		15 interacting genes: AGO1 AGO2 DCP2 EDC3 FHL2 LSM8 MAPK3 NSMAF PAXIP1 PNRC2 RITA1 SMAD4 TTF2 UPF1 YWHAG	9 interacting genes: ANXA10 DCP1A DCP1B DDX6 EFHC2 REEP5 YWHAB YWHAG ZFP36
Entrez ID		55802	80153
HPRD ID		06113	07954
Ensembl ID		ENSG00000272886	ENSG00000179151
Uniprot IDs		Q9NPI6	Q96F86
PDB IDs		2WX3 4B6H	2VC8 2WAX 2WAY 3D3J 3D3K 6S8S
Enriched GO Terms of Interacting Partners?
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