NGLY1 and GRM7

		NGLY1	GRM7
Description		N-glycanase 1	glutamate metabotropic receptor 7
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Integral Component Of Membrane Axon Dendrite Asymmetric Synapse Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding	Group III Metabotropic Glutamate Receptor Activity Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Glutamate Binding Serine Binding
	Biological Process	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation	Behavioral Fear Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Negative Regulation Of Glutamate Secretion Regulation Of Cyclase Activity Regulation Of Synaptic Transmission, Glutamatergic
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			Glutamic Acid
Diseases
GWAS			Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Airway imaging phenotypes ( 26030696) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Early response to risperidone in schizophrenia ( 26856250) Major depressive disorder (broad) ( 20038947) Night sleep phenotypes ( 27126917) Orofacial clefts ( 22419666) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Panic disorder ( 19165232) Personality traits in bipolar disorder ( 21368711) Plasma clusterin levels ( 26545630) Recurrent major depressive disorder ( 29317602) Response to fenofibrate (total cholesterol levels) ( 27002377) Systemic sclerosis ( 30247649) Telomere length ( 30185882) Urate levels in lean individuals ( 25811787) Uterine fibroid number (single vs multiple) ( 30196971) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		19 interacting genes: APP FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NSFL1C OPA3 PROC RAD23A RAD23B SH3BP1 SRPK2 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP	15 interacting genes: CALM1 CALM2 CALM3 FLNA GNAQ GRIP1 GRIPAP1 NGLY1 PICK1 SDCBP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8
Entrez ID		55768	2917
HPRD ID		10118	04979
Ensembl ID		ENSG00000151092	ENSG00000196277
Uniprot IDs		Q96IV0	B2R693 B9EGG9 Q14831 Q59G95
PDB IDs		2CCQ 2CM0	3MQ4 5C5C
Enriched GO Terms of Interacting Partners?
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