FEM1A and PTGER4

Number of citations of the paper that reports this interaction (PubMedID 16424369)
27

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		FEM1A	PTGER4
Description		fem-1 homolog A	prostaglandin E receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cell Plasma Membrane Integral Component Of Membrane
	Molecular Function	EP4 Subtype Prostaglandin E2 Receptor Binding	Prostaglandin E Receptor Activity Protein Binding
	Biological Process	Protein Ubiquitination Post-translational Protein Modification Negative Regulation Of Inflammatory Response Regulation Of Ubiquitin-protein Transferase Activity	Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Cytokine Secretion Positive Regulation Of Cytokine Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways		Neddylation	Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Dinoprostone Misoprostol Limaprost
Diseases
GWAS		Height ( 31562340)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187 21743469) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 17684544 22936669 22412388 26278503 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697 28445677) Pediatric autoimmune diseases ( 26301688) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Ulcerative colitis ( 21297633)
Interacting Genes		2 interacting genes: PPM1F PTGER4	1 interacting genes: FEM1A
Entrez ID		55527	5734
HPRD ID		16888	03350
Ensembl ID		ENSG00000141965	ENSG00000171522
Uniprot IDs		Q9BSK4	A0PJF5 P35408
PDB IDs			5YHL 5YWY
Enriched GO Terms of Interacting Partners?
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