HEMGN and H2AC6

Number of citations of the paper that reports this interaction (PubMedID 24740910)
9

Data Source:
BioGRID (two hybrid)

		HEMGN	H2AC6
Description		hemogen	H2A clustered histone 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	Multicellular Organism Development Cell Differentiation Regulation Of Osteoblast Differentiation	Chromatin Organization Chromatin Silencing Negative Regulation Of Cell Proliferation
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Quantitative traits ( 19197348) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		12 interacting genes: CTBP1 ENO1 EP300 GATA1 H2AC6 HMGA1 HSPA1A KAT6A MED17 SP100 THAP11 ZBTB1	3 interacting genes: HEMGN MTNR1A TFAP2B
Entrez ID		55363	8334
HPRD ID		17100	09104
Ensembl ID		ENSG00000136929	ENSG00000180573
Uniprot IDs		A0A024R162 Q9BXL5	A0A024R017 Q93077
PDB IDs			6C0W 6MUO 6MUP
Enriched GO Terms of Interacting Partners?
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