PPP3CA and CRTC2

Number of citations of the paper that reports this interaction (PubMedID 15454081)
246

Data Source:
HPRD (in vivo, in vitro)

		PPP3CA	CRTC2
Description		protein phosphatase 3 catalytic subunit alpha	CREB regulated transcription coactivator 2
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Plasma Membrane Z Disc Slit Diaphragm Sarcolemma Dendritic Spine Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Cyclosporin A Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein-containing Complex Binding Protein Dimerization Activity ATPase Binding	Chromatin Binding Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Wnt Signaling Pathway, Calcium Modulating Pathway Brain Development Aging Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Negative Regulation Of Chromatin Binding Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Skeletal Muscle Tissue Regeneration Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Calcium Ion Excitatory Postsynaptic Potential Peptidyl-serine Dephosphorylation Cellular Response To Glucose Stimulus Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Connective Tissue Replacement	Gluconeogenesis Viral Process Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Toxin Transport
Pathways		DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation	Transcriptional activation of mitochondrial biogenesis Circadian Clock
Drugs		Myristic acid
Diseases
GWAS		Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)	Age at first birth ( 27798627) Empathy quotient ( 29527006)
Interacting Genes		31 interacting genes: AATK AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SOD1 STUB1 SYNJ1 UBE4B	9 interacting genes: MFHAS1 PPP3CA PRKAA1 SIK1 SIK2 SIK3 YWHAB YWHAG YWHAZ
Entrez ID		5530	200186
HPRD ID		00234	12347
Ensembl ID		ENSG00000138814	ENSG00000160741
Uniprot IDs		A0A0S2Z4B5 A0A0S2Z4C6 Q08209	Q53ET0
PDB IDs		1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU	4HTM
Enriched GO Terms of Interacting Partners?
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