FBXW7 and CCNE2

Number of citations of the paper that reports this interaction (PubMedID 19084516)
19

Data Source:
BioGRID (enzymatic study)

		FBXW7	CCNE2
Description		F-box and WD repeat domain containing 7	cyclin E2
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex
	Molecular Function	Protein Binding Cyclin Binding Protein Binding, Bridging Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity	Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Protein Polyubiquitination Vasculogenesis Vasculature Development Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of Protein Localization Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Rhythmic Process Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Synapsis Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cellular Protein Localization
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition p53-Dependent G1 DNA Damage Response
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS
Interacting Genes		54 interacting genes: AHSG ANGPTL4 ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 EBNA1BP2 EXT1 EZH2 GATA2 GATA3 GLMN HEY1 HIPK2 HNRNPK IL24 JUN KLF10 KLF5 LINGO1 MAPK3 MCL1 MMS22L MYB MYC MYCN NOTCH1 NOTCH4 NPM1 PLK1 PPARGC1A PRKN PSEN1 PTPN11 RACK1 RFLNA SCGB3A1 SHPRH SKP1 SOX9 SREBF1 STOML1 STYX SUMF2 TSC22D4 USP9X WDR97	12 interacting genes: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXO7 FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		55294	9134
HPRD ID		05888	04801
Ensembl ID		ENSG00000109670	ENSG00000175305
Uniprot IDs		G0Z2K0 Q969H0 S4R3U4	A0A024R9B0 O96020
PDB IDs		2OVP 2OVQ 2OVR 5IBK 5V4B
Enriched GO Terms of Interacting Partners?
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