PPP2R5D and CRY2

Number of citations of the paper that reports this interaction (PubMedID 23555304)
16

Data Source:
BioGRID (two hybrid)

		PPP2R5D	CRY2
Description		protein phosphatase 2 regulatory subunit B'delta	cryptochrome circadian regulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol	Extracellular Region Nucleus Cytosol Nuclear Speck
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding FAD Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Nervous System Development Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation	Circadian Clock
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Estimated glomerular filtration rate ( 31015462)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)
Interacting Genes		16 interacting genes: CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C RORC SGO1 USHBP1	22 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 DELEC1 EZH2 LMNA MTUS2 NPAS2 PDE9A PER1 PER2 PER3 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGES2 STK11 TIMELESS TTC1
Entrez ID		5528	1408
HPRD ID		09039	07226
Ensembl ID		ENSG00000112640	ENSG00000121671
Uniprot IDs		A0A024RD11 Q14738	A0A0D2X7Z3 A2I2P1 Q49AN0
PDB IDs
Enriched GO Terms of Interacting Partners?
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