PRMT6 and SPSB1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
38

Data Source:
BioGRID (two hybrid)

		PRMT6	SPSB1
Description		protein arginine methyltransferase 6	splA/ryanodine receptor domain and SOCS box containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Chromatin Binding Protein Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)	Protein Binding Protein Binding, Bridging Involved In Substrate Recognition For Ubiquitination
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Base-excision Repair Regulation Of Mitochondrion Organization Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Histone Deacetylation Histone H3-R2 Methylation Histone H4-R3 Methylation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Histone H3-K4 Methylation Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Height ( 28552196 31562340) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 27841878 30578418) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4-16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	10 interacting genes: ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1
Entrez ID		55170	80176
HPRD ID		10505	18106
Ensembl ID		ENSG00000198890	ENSG00000171621
Uniprot IDs		Q96LA8	A0A024R4G8 Q96BD6
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I	2JK9 3F2O
Enriched GO Terms of Interacting Partners?
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