DARS2 and KARS1

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical, two hybrid)

		DARS2	KARS1
Description		aspartyl-tRNA synthetase 2, mitochondrial	lysyl-tRNA synthetase 1
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Extracellular Space Nucleus Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity	TRNA Binding ATP Adenylyltransferase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Activation Of MAPK Activity Basophil Activation Involved In Immune Response Positive Regulation Of Cytokine Secretion Involved In Immune Response TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Negative Regulation Of Cell Proliferation Response To X-ray Positive Regulation Of Macrophage Chemotaxis Diadenosine Tetraphosphate Biosynthetic Process Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Metallopeptidase Activity
Pathways		Mitochondrial tRNA aminoacylation	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs		L-Aspartic Acid	L-Lysine
Diseases		Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		4 interacting genes: AIMP2 DPYSL5 EPHA8 KARS1	16 interacting genes: AIMP2 DARS2 EEF1D EEF1G ESR1 FRS3 GAPDH GEMIN4 MAPK1 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 VIM
Entrez ID		55157	3735
HPRD ID		07677	03249
Ensembl ID		ENSG00000117593	ENSG00000065427
Uniprot IDs		Q6PI48 Q9H9J7	Q15046
PDB IDs		4AH6	3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH
Enriched GO Terms of Interacting Partners?
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