PPP1R2 and NEK2

Number of citations of the paper that reports this interaction (PubMedID 12221103)
27

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vivo, in vitro)

		PPP1R2	NEK2
Description		protein phosphatase 1 regulatory inhibitor subunit 2	NIMA related kinase 2
Image		No pdb structure
GO Annotations	Cellular Component		Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein-containing Complex
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding
	Biological Process	Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Signal Transduction Negative Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Phosphoprotein Phosphatase Activity	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Positive Regulation Of Telomerase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Telomere Capping
Pathways			APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
Diseases
GWAS			Red cell distribution width ( 27863252 28957414)
Interacting Genes		12 interacting genes: CDK5 CSNK2A1 CSNK2A2 GSK3B LMTK2 NEK2 PPP1CA PPP1CC PPP1R9A PPP1R9B TERF2IP TINF2	28 interacting genes: CCDC85A CDC20 CEP250 CHGA CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3
Entrez ID		5504	4751
HPRD ID		03478	04953
Ensembl ID		ENSG00000184203	ENSG00000117650
Uniprot IDs		P41236	F6U4U2 P51955
PDB IDs			2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6H0O
Enriched GO Terms of Interacting Partners?
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