AUP1 and ITGA2B

Number of citations of the paper that reports this interaction (PubMedID 12042322)
9

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		AUP1	ITGA2B
Description		AUP1 lipid droplet regulating VLDL assembly factor	integrin subunit alpha 2b
Image
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Membrane Integral Component Of Endoplasmic Reticulum Membrane Extracellular Exosome	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Ubiquitin Binding Ubiquitin-protein Transferase Activator Activity	Protein Binding Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Regulation Of Catalytic Activity	Platelet Degranulation Positive Regulation Of Leukocyte Migration Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization Regulation Of Megakaryocyte Differentiation Platelet Aggregation
Pathways			Platelet degranulation Integrin cell surface interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Signaling downstream of RAS mutants
Drugs			Abciximab Tirofiban Lefradafiban
Diseases			Glanzmann thrombasthenia
GWAS			Mean platelet volume ( 27863252) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252)
Interacting Genes		7 interacting genes: ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11	20 interacting genes: APP AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA FGG FN1 GRB2 ITGB3 PLA2G4A PRKACA SHARPIN TLN1 VWF
Entrez ID		550	3674
HPRD ID		03892	06377
Ensembl ID		ENSG00000115307	ENSG00000005961
Uniprot IDs		Q9Y679	P08514
PDB IDs		2EKF	1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TYE 1UV9 2K1A 2K9J 2KNC 2MTP 2N9Y 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4Z7N 4Z7O 4Z7Q 5HDB
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?