BCAS3 and ATM

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		BCAS3	ATM
Description		BCAS3 microtubule associated cell migration factor	ATM serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoplasmic Microtubule Cell Leading Edge Transcriptionally Active Chromatin Intermediate Filament Cytoskeleton Cell Periphery	Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Cell Nucleus Nucleoplasm Nucleolus Spindle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle DNA Repair Complex
	Molecular Function	Chromatin Binding Protein Binding Transcription Factor Binding Acetyltransferase Activator Activity Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Binding Beta-tubulin Binding	DNA Binding Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Identical Protein Binding Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Angiogenesis Golgi Organization Positive Regulation Of Endothelial Cell Migration Microtubule Organizing Center Organization Negative Regulation Of GTPase Activity Tube Formation Response To Starvation Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Filopodium Assembly Negative Regulation Of Focal Adhesion Assembly Cellular Response To Estrogen Stimulus Positive Regulation Of Intracellular Protein Transport Activation Of GTPase Activity Regulation Of Establishment Of Cell Polarity Positive Regulation Of Actin Cytoskeleton Reorganization	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Ovarian Follicle Development Response To Hypoxia Somitogenesis Pre-B Cell Allelic Exclusion Immunoglobulin Production DNA Replication Double-strand Break Repair Via Nonhomologous End Joining Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiotic Nuclear Division Signal Transduction Brain Development Heart Development Determination Of Adult Lifespan Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To Ionizing Radiation Regulation Of Autophagy Positive Regulation Of Gene Expression Histone Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Histone Phosphorylation V(D)J Recombination Multicellular Organism Growth Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Meiotic Telomere Clustering Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Thymus Development Oocyte Development Neuron Apoptotic Process Regulation Of Telomerase Activity Histone MRNA Catabolic Process Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Cellular Response To X-ray Cellular Response To Nitrosative Stress Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of DNA Catabolic Process Regulation Of Microglial Cell Activation Negative Regulation Of TORC1 Signaling Negative Regulation Of Telomere Capping Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomerase Catalytic Core Complex Assembly Regulation Of Cellular Response To Gamma Radiation
Pathways			DNA Damage/Telomere Stress Induced Senescence Regulation of HSF1-mediated heat shock response Autodegradation of the E3 ubiquitin ligase COP1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Caspase Activators and Caspases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Meiotic recombination Pexophagy
Drugs			Caffeine
Diseases			Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Chronic lymphocytic leukemia (CLL)
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Alzheimer's disease (cognitive decline) ( 23535033) Blood urea nitrogen levels ( 31152163 29403010) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Calcium levels ( 29403010) Chronic kidney disease ( 31152163 20383146) Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708 29779033 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gout ( 25967671) Heel bone mineral density ( 30598549 28869591) Height ( 18391951) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Immune reponse to smallpox (secreted IL-2) ( 22610502) Intraocular pressure ( 29617998 29785010 31959993 30054594) Lung function (FEV1/FVC) ( 30804560) Macular thickness ( 30535121) Medial orbital frontal cortex volume ( 31530798) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels (small molecules and protein measures) ( 27005778) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Pulse pressure ( 30578418) Red blood cell count ( 27863252) Renal function-related traits (BUN) ( 22797727) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29403010) Systolic blood pressure ( 30224653 30578418) Thyroid stimulating hormone levels ( 30367059) Urate levels ( 31578528 23263486) Urolithiasis ( 30975718) Vertical cup-disc ratio ( 20548946) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alzheimer's disease (late onset) ( 28714976) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866) Leukocyte telomere length ( 31171785) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Nonunion in individuals with fractures ( 30680360) Prostate cancer ( 29892016) Red blood cell count ( 29403010) Renal cell carcinoma ( 28598434) Response to metformin in type 2 diabetes (glycemic) ( 21186350) Rheumatoid arthritis ( 30423114 24390342) Sum eosinophil basophil counts ( 27863252) Uterine fibroids ( 30194396)
Interacting Genes		20 interacting genes: ATM BAG4 CCND1 CDC23 CTBP1 CTBP2 FBXW7 H3C1 KRAS MTDH PALB2 PELP1 PHB PTPN1 SMAD4 STK11 TGFB1 TSG101 XRCC3 ZDHHC17	97 interacting genes: AATF ABL1 ACTL6B AP1B1 AP2B1 AP3B1 AP3B2 ATR BCAS3 BCL10 BRCA1 BRCA2 CDC6 CDKN2C CHD4 CHEK1 CHEK2 COPS5 CREB1 CRX CSNK1D CXXC5 DAXX DCAF1 DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 ERRFI1 EXO1 FANCD2 FECH FOXO3 H2AX HIF1A HSPA8 IL24 KAT5 KAT8 LIG4 MAP1S MCM2 MCPH1 MDC1 MDM2 MDM4 MRE11 MT-ND4 MTA3 NBN NR4A1 NREP NSD3 OSGIN1 PARP1 PEX5 POLR2A PPP2R5C PRKDC PTCH1 RAD17 RAD51 RAD9A RANBP9 RASSF1 RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 SMC1A SPSB1 STK11 TCL1A TELO2 TERF1 TERF2 TFF1 TIPARP TOP1 TOPBP1 TP53 TP53BP1 TRAF6 TREX1 TRIM29 UCHL3 WRN XPA XRCC5 ZEB1 ZNF821
Entrez ID		54828	472
HPRD ID		06313	06347
Ensembl ID		ENSG00000141376	ENSG00000149311
Uniprot IDs		K7ESE9 Q05D99 Q9H6U6	A0A024R3C7 Q13315
PDB IDs			5NP0 5NP1 6HKA
Enriched GO Terms of Interacting Partners?
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