GATAD2A and SPOP

Number of citations of the paper that reports this interaction (PubMedID 29996942)
5

Data Source:
BioGRID (two hybrid)

		GATAD2A	SPOP
Description		GATA zinc finger domain containing 2A	speckle type BTB/POZ protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm NuRD Complex Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein Binding, Bridging Sequence-specific DNA Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Negative Regulation Of Transcription, DNA-templated	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Hedgehog 'on' state
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Height ( 25282103 31562340) Nonalcoholic fatty liver disease ( 29385134) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia ( 25056061 29483656 23974872) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)	Prostate cancer ( 23535732)
Interacting Genes		11 interacting genes: CREBBP H2AC20 H2BC21 H3C1 H4C1 KAT2B KRT40 MBD2 MBD3 PAK4 SPOP	69 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRD4 BRMS1 CACUL1 CAPRIN1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GLI3 GMEB1 HCST HMGCS1 INF2 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8
Entrez ID		54815	8405
HPRD ID		11741	16004
Ensembl ID		ENSG00000167491	ENSG00000121067
Uniprot IDs		A0A024R7K7 A0A024R7M6 Q86YP4	O43791
PDB IDs		2L2L	2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A
Enriched GO Terms of Interacting Partners?
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