OTUD4 and STAT1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		OTUD4	STAT1
Description		OTU deubiquitinase 4	signal transducer and activator of transcription 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Molecular Adaptor Activity Lys63-specific Deubiquitinase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin-like Protein Ligase Binding Cadherin Binding Protein Phosphatase 2A Binding Repressing Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Protein Deubiquitination Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Defense Response Positive Regulation Of Transcription Of Notch Receptor Target JAK-STAT Cascade Response To Nutrient Blood Circulation Response To Mechanical Stimulus Macrophage Derived Foam Cell Differentiation Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-alpha Production Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Interferon-beta Cellular Response To Interferon-beta Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Renal Tubule Development Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Organic Cyclic Compound Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Pathways			Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Regulation of RUNX2 expression and activity Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Growth hormone receptor signaling
Drugs
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF) IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412) Lung function (FEV1) ( 30061609) Metabolite levels ( 31628463) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Birth weight ( 31043758) Height ( 31562340) Inflammatory bowel disease ( 23128233) JT interval (sulfonylurea treatment interaction) ( 27958378) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer (SNP x SNP interaction) ( 24325914) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 26394269) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 26316170) Systemic sclerosis ( 29293537)
Interacting Genes		8 interacting genes: ALKBH3 EXOSC8 MAVS REL STAT1 TCF4 UBC USP7	107 interacting genes: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DDX6 DOT1L DUSP2 DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 FADD FANCC FGFR3 FGFR4 FLT1 FOS FTH1 FYN GFAP GTF2I HADH HLA-B HSF1 HSP90AB1 HSPA8 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK MT-ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RACK1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTB SPTBN1 SRC STAT2 STAT3 STAT4 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBE2I VDR XPO1 ZNF467
Entrez ID		54726	6772
HPRD ID		11033	02777
Ensembl ID		ENSG00000164164	ENSG00000115415
Uniprot IDs		Q01804	P42224
PDB IDs			1BF5 1YVL 2KA6 3WWT
Enriched GO Terms of Interacting Partners?
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