PPARD and ITGB5

Number of citations of the paper that reports this interaction (PubMedID 15604093)
54

Data Source:
BioGRID (two hybrid)

		PPARD	ITGB5
Description		peroxisome proliferator activated receptor delta	integrin subunit beta 5
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Fatty Acid Binding Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Lipid Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity NF-kappaB Binding Linoleic Acid Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Vitamin A Metabolic Process Apoptotic Process Multicellular Organism Development Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process MRNA Transcription Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Transport Regulation Of Lipid Metabolic Process Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Response To Nutrient Levels Positive Regulation Of Insulin Secretion Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Response To Lipid Wound Healing Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Regeneration Keratinocyte Proliferation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Adipose Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Lipid Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Blood Vessel Diameter Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Glucose Transmembrane Transport Positive Regulation Of Myoblast Proliferation	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Muscle Contraction Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Stress Fiber Assembly Viral Entry Into Host Cell Epithelial Cell-cell Adhesion
Pathways		Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Nuclear Receptor transcription pathway Signaling by Retinoic Acid	Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction
Drugs		Alpha-Linolenic Acid Icosapent Troglitazone Valproic Acid Treprostinil Rosiglitazone Sulindac Fenofibrate Pioglitazone Bezafibrate Phthalic Acid Heptyl-Beta-D-Glucopyranoside Oleic Acid (11E)-OCTADEC-11-ENOIC ACID Elafibranor KD3010 GW-501516 (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid Indeglitazar {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Clinofibrate Glycerin
Diseases
GWAS		Cataracts in type 2 diabetes ( 23137000) Gout ( 22179738) Heel bone mineral density ( 30598549) Height ( 21998595 28552196) Lymphocyte counts ( 27863252) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266)	Airway hyperresponsiveness ( 23984888) Carpal tunnel syndrome ( 30833571) Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		40 interacting genes: BCL6 CEP350 DUT EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NRIP1 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 PSMC5 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC STAT3 TNP1	36 interacting genes: ANXA5 CCN1 DAB1 DAB2 DOK1 EHMT2 EPS8 EWSR1 FHL2 FLNA ITGA5 ITGAV ITGB3BP KRT40 KRTAP10-8 KRTAP10-9 LTBP1 LTBP3 MTDH MTUS2 MYO10 NOTCH2NLA NUMB P2RY2 PAK4 PALLD PPARD PTK2 RACK1 SNTA1 SPP1 SRSF9 STAB2 TLN1 TNS2 ZBTB17
Entrez ID		5467	3693
HPRD ID		02679	00949
Ensembl ID		ENSG00000112033	ENSG00000082781
Uniprot IDs		A0A024RCW6 F1D8S7 Q03181	D3DNA1 L7RT22 P18084
PDB IDs		1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM 5U3Q 5U3R 5U3S 5U3T 5U3U 5U3V 5U3W 5U3X 5U3Y 5U3Z 5U40 5U41 5U42 5U43 5U44 5U45 5U46 5XMX 5Y7X 5ZXI 6A6P
Enriched GO Terms of Interacting Partners?
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