PAF1 and TCEA1

Number of citations of the paper that reports this interaction (PubMedID 20178742)
125

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		PAF1	TCEA1
Description		PAF1 homolog, Paf1/RNA polymerase II complex component	transcription elongation factor A1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex Cell Junction Transcriptionally Active Chromatin	Nucleoplasm Transcription Factor TFIID Complex Nucleolus
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Nucleosome Positioning Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition	Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Exoribonuclease Activity
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		13 interacting genes: EXOSC5 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A MLLT1 MSL1 MSL2 MSL3 RNF20 TCEA1	17 interacting genes: APP CDC73 CDK7 CIR1 CTDP1 CTR9 EAF2 GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 UBR5 WDR61
Entrez ID		54623	6917
HPRD ID		10140	03252
Ensembl ID		ENSG00000006712	ENSG00000187735
Uniprot IDs		A0A024R0H6 Q8N7H5	A0A384MTX4 B7Z4W0 P23193
PDB IDs		4M6T 5ZYQ 6GMH	1TFI 3NDQ 5IY6 5IY7 5IY8 5IYA 5IYB 5IYC 6O9L
Enriched GO Terms of Interacting Partners?
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