POU5F1 and FOXD3

Number of citations of the paper that reports this interaction (PubMedID 11891324)
47

Data Source:
HPRD (in vitro)

		POU5F1	FOXD3
Description		POU class 5 homeobox 1	forkhead box D3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Blastocyst Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Cell Differentiation Somatic Stem Cell Population Maintenance MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Silencing By MiRNA	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Cell Differentiation Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cold sores ( 28928442) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21801394) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Multiple myeloma ( 23955597) Night sleep phenotypes ( 27126917) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Type 2 diabetes ( 24509480 30718926 28869590) Ulcerative colitis ( 28067908)
Interacting Genes		15 interacting genes: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH LRRK2 MNAT1 NR0B1 SOX10 SOX2 SOX8 STUB1 WDR5	2 interacting genes: PABPC4 POU5F1
Entrez ID		5460	27022
HPRD ID		01252	07018
Ensembl ID		ENSG00000204531	ENSG00000187140
Uniprot IDs		D2IYK3 F2Z381 M1S623 Q01860	Q9UJU5
PDB IDs
Enriched GO Terms of Interacting Partners?
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