POU3F3 and PPP1R15A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		POU3F3	PPP1R15A
Description		POU class 3 homeobox 3	protein phosphatase 1 regulatory subunit 15A
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Homodimerization Activity Sequence-specific DNA Binding HMG Box Domain Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Protein Phosphatase Activator Activity
	Biological Process	Central Nervous System Development Excretion Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Cell Differentiation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Chemical Homeostasis Metanephric Ascending Thin Limb Development Metanephric Macula Densa Development Metanephric Thick Ascending Limb Development Metanephric Loop Of Henle Development Metanephric DCT Cell Differentiation	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Dephosphorylation Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Dephosphorylation
Pathways			Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Body mass index ( 26426971) General risk tolerance (MTAG) ( 30643258) Response to taxane treatment (docetaxel) ( 23006423)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		5 interacting genes: POU3F4 PPP1R15A SOX10 SOX11 SOX8	16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		5455	23645
HPRD ID		03922	06572
Ensembl ID		ENSG00000198914	ENSG00000087074
Uniprot IDs		P20264	O75807
PDB IDs			4XPN
Enriched GO Terms of Interacting Partners?
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