USP53 and NECTIN2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		USP53	NECTIN2
Description		ubiquitin specific peptidase 53	nectin cell adhesion molecule 2
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cell-cell Junction Bicellular Tight Junction	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Cell-cell Contact Zone Extracellular Exosome
	Molecular Function	Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Action Potential Sensory Perception Of Sound Biological_process Response To Auditory Stimulus Protein Deubiquitination Neuron Apoptotic Process	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS		Body mass index ( 29273807)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: CRK DAB1 GRB2 IREB2 NECTIN2 TRAF2 UBC	20 interacting genes: AFDN ATP5MF CD226 DUS2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP5-9 LYRM4 MAPK6 MDFI NECTIN3 NECTIN4 NOTCH2NLA PICK1 PVR SIAH1 TIGIT USP53
Entrez ID		54532	5819
HPRD ID		11669	02879
Ensembl ID		ENSG00000145390	ENSG00000130202
Uniprot IDs		Q70EK8 Q9H9I0	Q92692
PDB IDs			3R0N 4DFH 4DFI 4HZA 5V52
Enriched GO Terms of Interacting Partners?
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