POU2F1 and TLX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		POU2F1	TLX2
Description		POU class 2 homeobox 1	T cell leukemia homeobox 2
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Cellular_component Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding
	Biological Process	Cytokine-mediated Signaling Pathway Cell Differentiation SnRNA Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Mesoderm Formation Positive Regulation Of Transcription By RNA Polymerase II Enteric Nervous System Development Negative Regulation Of Dendrite Morphogenesis
Pathways		Interleukin-4 and Interleukin-13 signaling RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Asthma ( 31619474) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Liver enzyme levels ( 18940312) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		49 interacting genes: APP AR BARD1 BRCA1 CEBPE CREB1 ESR1 FDXR HCFC1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 PRKACA PRKDC RARA RELA RXRA SNAPC4 SOX2 SP1 SP4 STAT5A STAT5B TBP THRA TLE4 TLE5 TLX2 TNF TXNRD1 VDR XRCC6	9 interacting genes: GTF2A1L IRF6 IRF9 MCM4 MEIS1 POU2F1 TLE1 YWHAH ZNF502
Entrez ID		5451	3196
HPRD ID		01250	07254
Ensembl ID		ENSG00000143190	ENSG00000115297
Uniprot IDs		A0A024R8Y2 P14859	O43763
PDB IDs		1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU	3A03
Enriched GO Terms of Interacting Partners?
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