DGCR8 and DROSHA

Number of citations of the paper that reports this interaction (PubMedID 15574589)
670

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DGCR8	DROSHA
Description		DGCR8 microprocessor complex subunit	drosha ribonuclease III
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Microprocessor Complex	Nucleus Nucleoplasm Nucleolus Postsynaptic Density Microprocessor Complex
	Molecular Function	Double-stranded RNA Binding Ribonuclease III Activity Protein Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Primary MiRNA Binding	Lipopolysaccharide Binding RNA Binding Double-stranded RNA Binding Ribonuclease III Activity Protein Binding DEAD/H-box RNA Helicase Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding R-SMAD Binding Primary MiRNA Binding
	Biological Process	MiRNA Metabolic Process Primary MiRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	RNA Processing MiRNA Metabolic Process Positive Regulation Of Gene Expression RRNA Catabolic Process Production Of SiRNA Involved In RNA Interference Primary MiRNA Processing Pre-miRNA Processing Ribosome Biogenesis Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of MiRNA Metabolic Process
Pathways		MicroRNA (miRNA) biogenesis Transcriptional Regulation by MECP2	MicroRNA (miRNA) biogenesis
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Serum metabolite levels ( 23093944)	Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Lung function (FEV1) ( 26635082) Tuberculosis ( 30713548)
Interacting Genes		3 interacting genes: APP DROSHA MEOX2	3 interacting genes: DGCR8 SP1 ZNF512B
Entrez ID		54487	29102
HPRD ID		09913	10196
Ensembl ID		ENSG00000128191	ENSG00000113360
Uniprot IDs		Q8WYQ5	Q9NRR4
PDB IDs		1X47 2YT4 3LE4 5B16	2KHX 2NA2 5B16
Enriched GO Terms of Interacting Partners?
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