RNF216 and TLR9

Number of citations of the paper that reports this interaction (PubMedID 15107846)
102

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RNF216	TLR9
Description		ring finger protein 216	toll like receptor 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse	Golgi Membrane Extracellular Region Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Early Phagosome Endolysosome Endolysosome Membrane
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding SiRNA Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity Unmethylated CpG Binding
	Biological Process	Apoptotic Process Viral Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission	Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of Immunoglobulin Production MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Positive Regulation Of Gene Expression Maintenance Of Gastrointestinal Epithelium Positive Regulation Of B Cell Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Tumor Necrosis Factor Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Regulation Of B Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Calcium-transporting ATPase Activity
Pathways		Negative regulators of DDX58/IFIH1 signaling	PI3K Cascade Trafficking and processing of endosomal TLR Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs			Chloroquine Hydroxychloroquine ISS-1018 Golotimod CPG 10101
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Feeling nervous ( 29500382) General cognitive ability ( 29844566) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		19 interacting genes: AGFG1 BRCA1 KIR2DL4 MAPK1 RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TRAF3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6	6 interacting genes: BTK HRAS MAPK8IP3 RNF216 SIGIRR TLR1
Entrez ID		54476	54106
HPRD ID		15550	05685
Ensembl ID		ENSG00000011275	ENSG00000239732
Uniprot IDs		A8K8N1 Q9NWF9	Q9NR96
PDB IDs
Enriched GO Terms of Interacting Partners?
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