POMC and MC2R

Number of citations of the paper that reports this interaction (PubMedID 12213892)
14

Data Source:
HPRD (in vivo)

		POMC	MC2R
Description		proopiomelanocortin	melanocortin 2 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion	Placenta Development G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors G alpha (s) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) ADORA2B mediated anti-inflammatory cytokines production
Drugs		Loperamide Etorphine Dihydromorphine	Tetracosactide Corticotropin
Diseases			Adrenal carcinoma
GWAS		Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)	Negative urgency ( 30718321) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
Interacting Genes		12 interacting genes: APP FGF10 HLA-DRB3 MC1R MC2R MC3R MC4R MC5R MEP1A NRDC PAM VTN	2 interacting genes: ASIP POMC
Entrez ID		5443	4158
HPRD ID		01462	06304
Ensembl ID		ENSG00000115138	ENSG00000185231
Uniprot IDs		P01189	Q01718
PDB IDs		4XNH 4XPD 4Y49
Enriched GO Terms of Interacting Partners?
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