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POLR2A and GTF2H1
Number of citations of the paper that reports this interaction (PubMedID
8934526
)
106
Data Source:
BioGRID
(enzymatic study, biochemical)
POLR2A
GTF2H1
Description
RNA polymerase II subunit A
general transcription factor IIH subunit 1
Image
GO Annotations
Cellular Component
Prp19 Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Nucleolus
Cytoplasm
Transcription Factor TFIIH Core Complex
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Molecular Function
RNA Polymerase II Activity
DNA Binding
RNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
RNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Protein C-terminus Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Promoter-specific Chromatin Binding
Chromatin Binding
Protein Kinase Activity
Protein Binding
DNA-dependent ATPase Activity
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Biological Process
MRNA Splicing, Via Spliceosome
Transcription, RNA-templated
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
DNA-templated Transcription, Termination
Regulation Of Transcription, DNA-templated
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
RNA Metabolic Process
Positive Regulation Of RNA Splicing
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Transcription By RNA Polymerase I
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Nucleotide-excision Repair, DNA Incision
Positive Regulation Of Transcription By RNA Polymerase II
Phosphorylation Of RNA Polymerase II C-terminal Domain
Global Genome Nucleotide-excision Repair
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS
Atrial fibrillation (
29892015
)
Central corneal thickness (
29760442
)
Heel bone mineral density (
30598549
)
Myopia (
27182965
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Amyloid A serum levels (
21124955
)
Blood protein levels (
28240269
)
Pancreatic cancer (
23180869
)
Serum metabolite levels (
23093944
)
Survival in pancreatic cancer (
28470677
)
Interacting Genes
104 interacting genes:
ABL1
ACTB
ACTL6A
ATM
BARD1
BRCA1
CALCOCO1
CALCOCO2
CASP10
CCNH
CCNK
CCNL2
CCNT1
CDC14A
CDK12
CDK7
CDK8
CDK9
CPSF1
CPSF2
CPSF3
CREBBP
CSH2
CSNK2A1
CSTF1
CSTF2
CTCF
CTDP1
CTDSP1
CTDSP2
DHX9
ELL
ELOA
ERCC5
ERCC6
ERG
ESR1
FUS
GRB2
GTF2B
GTF2E1
GTF2F1
GTF2F2
GTF2H1
GTF2H4
H1-2
HNRNPF
HNRNPU
HTATSF1
ITCH
IWS1
KAT2B
KLK2
KMT2D
LEO1
MCM3
MED21
MNAT1
MYH6
NEDD4
NONO
NR0B2
NSD1
OTUD5
PCIF1
PHF8
PIN1
POLR2C
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2I
POLR2L
PPIG
PPP1CA
PQBP1
PRMT5
PRPF19
SAFB
SKP2
SMN1
SMN2
SMURF1
SNAR-B2
SND1
SUB1
SUPT5H
TAF10
TBP
TCEA1
TCERG1
TRAK1
TRAM2
TTK
U2AF2
UBE2L3
UPF1
VDR
WAC
XAB2
XRCC5
ZNF74
44 interacting genes:
ACTN1
AR
ATF7IP
BRPF1
CCNH
CCSER2
CDK7
E2F1
ERCC2
ERCC3
ERCC4
ERCC5
ESR1
FUBP1
GTF2E1
GTF2E2
GTF2H2
GTF2H3
HNF4A
HNRNPU
HOXC11
JDP2
KIF13A
KPNA3
MCM2
MMS19
MNAT1
PIK3R1
PLCG1
POLR2A
POU2AF1
PSMC2
RAD23A
REEP5
RXRB
TNIP1
TP53
TRIOBP
TXNRD2
UBC
USHBP1
XPA
XPC
ZSCAN1
Entrez ID
5430
2965
HPRD ID
08916
01807
Ensembl ID
ENSG00000181222
ENSG00000110768
Uniprot IDs
A0A590UJN4
P24928
A0A384MTQ8
P32780
PDB IDs
2GHQ
2GHT
2LTO
3D9K
3D9L
3D9M
3D9N
3D9O
3D9P
4JXT
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5M3H
5M3J
6DRD
6F5P
6G0R
6O9L
1PFJ
2DII
2RNR
2RUK
2RVB
5GOW
5XV8
6NMI
6O9L
6O9M
Enriched GO Terms of Interacting Partners
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