RAB4B and RAB7A

Number of citations of the paper that reports this interaction (PubMedID 10329441)
20

Data Source:
BioGRID (two hybrid)

		RAB4B	RAB7A
Description		RAB4B, member RAS oncogene family	RAB7A, member RAS oncogene family
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GO Annotations	Cellular Component	Endosome Plasma Membrane Endomembrane System Secretory Granule Membrane Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome	Autophagosome Membrane Cell Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Endomembrane System Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Molecular_function GTPase Activity Protein Binding GTP Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Intracellular Protein Transport Regulation Of Endocytosis Rab Protein Signal Transduction Neutrophil Degranulation Glucose Import	Autophagosome Assembly Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Rab Protein Signal Transduction Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways		Neutrophil degranulation RAB geranylgeranylation MET receptor recycling	MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs			Guanosine-5'-Diphosphate
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood protein levels ( 28240269) Chronic obstructive pulmonary disease ( 22080838 28166215) Emphysema imaging phenotypes ( 26030696) Kawasaki disease ( 22081228) Smoking behaviour (cigarettes smoked per day) ( 30617275)	Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		3 interacting genes: EXOC5 RAB7A RABAC1	35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2
Entrez ID		53916	7879
HPRD ID		11473	03805
Ensembl ID		ENSG00000167578	ENSG00000075785
Uniprot IDs		A0A024R0K8 P61018	A0A158RFU6 P51149
PDB IDs		2O52	1T91 1YHN 3LAW 6IYB
Enriched GO Terms of Interacting Partners?
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