PMP22 and CANX

Number of citations of the paper that reports this interaction (PubMedID 12119418)
45

Data Source:
HPRD (in vivo)

		PMP22	CANX
Description		peripheral myelin protein 22	calnexin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Compact Myelin Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Protein-containing Complex Melanosome Neuronal Cell Body Dendritic Spine Mitochondria-associated ER Membrane Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Protein Binding	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Unfolded Protein Binding
	Biological Process	Chemical Synaptic Transmission Peripheral Nervous System Development Cell Death Negative Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Bleb Assembly Myelin Assembly Myelination	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Protein Folding In Endoplasmic Reticulum Synaptic Vesicle Endocytosis Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Clathrin-dependent Endocytosis
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs			Antihemophilic factor, human recombinant Tenecteplase Calcium Citrate Calcium Phosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)	Daytime sleep phenotypes ( 27126917) Myeloid white cell count ( 27863252) Resting heart rate ( 24680774) White blood cell count ( 27863252)
Interacting Genes		8 interacting genes: CANX CREB3 DDX52 KLRC1 LMNA MPZ PEX19 SMIM3	44 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 NUTF2 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR
Entrez ID		5376	821
HPRD ID		03059	00252
Ensembl ID		ENSG00000109099	ENSG00000127022
Uniprot IDs		A8MU75 Q01453 Q6FH25	P27824
PDB IDs
Enriched GO Terms of Interacting Partners?
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