PLTP and APOA2

Number of citations of the paper that reports this interaction (PubMedID 9469594)
11

Data Source:
HPRD (in vitro)

		PLTP	APOA2
Description		phospholipid transfer protein	apolipoprotein A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle	Extracellular Region Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome Blood Microparticle
	Molecular Function	Phosphatidylethanolamine Binding Phosphatidylcholine Transporter Activity Diacylglycerol Binding Phosphatidylcholine Binding Phosphatidic Acid Binding Ceramide Binding Intermembrane Ceramide Transfer Activity Intermembrane Phosphotidylcholine Transfer Activity Phosphatidylglycerol Binding Phosphatidylethanolamine Transporter Activity Phosphatidic Acid Transporter Activity	Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Intermembrane Cholesterol Transfer Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Vitamin E Biosynthetic Process Positive Regulation Of Cholesterol Efflux Phospholipid Transport Flagellated Sperm Motility High-density Lipoprotein Particle Remodeling Ceramide Transport Glycolipid Transport	Retinoid Metabolic Process Acute Inflammatory Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Positive Regulation Of Cholesterol Esterification Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Viral Process Protein Oxidation Peptidyl-methionine Modification Regulation Of Lipid Metabolic Process Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Animal Organ Regeneration Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Response To Estrogen Post-translational Protein Modification Reverse Cholesterol Transport Cellular Protein Metabolic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Diacylglycerol Catabolic Process Positive Regulation Of Phagocytosis Protein Stabilization Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Response To Glucocorticoid Negative Regulation Of Lipase Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Cholesterol Transporter Activity
Pathways			PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Zinc Copper
Diseases			Familial amyloidosis
GWAS		Blood protein levels ( 29875488) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Experiencing mood swings ( 29500382) Gut microbiota (functional units) ( 27694959) HDL cholesterol ( 24097068 28270201 19060906 25961943 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) Inflammatory bowel disease ( 23128233) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Neurociticism ( 29500382) Pathological gambling ( 27315593) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 28334899 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 19060906 25961943 20686565)
Interacting Genes		5 interacting genes: ABCA1 APOA1 APOA2 APOE CREB3	15 interacting genes: ABCA13 APOA1 APOC1 APOD APOF C4A CATSPER1 CREB3 LMNA NAXE NDRG1 PLTP SCARB1 TREM2 VKORC1
Entrez ID		5360	336
HPRD ID		01399	00129
Ensembl ID		ENSG00000100979	ENSG00000158874
Uniprot IDs		P55058	P02652
PDB IDs
Enriched GO Terms of Interacting Partners?
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