ATP6V0A1 and CLIC1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ATP6V0A1	CLIC1
Description		ATPase H+ transporting V0 subunit a1	chloride intracellular channel 1
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Cell Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Integral Component Of Membrane Vacuolar Proton-transporting V-type ATPase Complex Nuclear Speck Secretory Granule Membrane Phagocytic Vesicle Membrane Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Membrane	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding Cadherin Binding
	Biological Process	Vacuolar Acidification Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Neutrophil Degranulation Phagosome Acidification Toxin Transport Proton Transmembrane Transport	Chloride Transport Signal Transduction Regulation Of Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs			Copper Artenimol
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 27863252) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: CLIC1 CYTH2 SEH1L SNX4 ZNF267	20 interacting genes: AKAP9 ALOX5AP ATP5PB ATP6V0A1 ATP6V0C CPT1A DNAJC19 IKBKG LSM1 MYOC NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TRAPPC2 ZNF184 ZNF302
Entrez ID		535	1192
HPRD ID		01886	04188
Ensembl ID		ENSG00000033627	ENSG00000213719
Uniprot IDs		Q53ET5 Q53X12 Q5CZH6 Q93050	O00299 Q53FB0 Q5SRT3
PDB IDs			1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA 4JZQ 4K0G 4K0N
Enriched GO Terms of Interacting Partners?
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