PLG and HMGB1

Number of citations of the paper that reports this interaction (PubMedID 1909331)
18

Data Source:
HPRD (in vitro)

		PLG	HMGB1
Description		plasminogen	high mobility group box 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nuclear Chromatin Condensed Chromosome Extracellular Region Extracellular Space Cell Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Transcriptional Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding Kinase Binding Protein Domain Specific Binding Apolipoprotein Binding Chaperone Binding Proteasome Core Complex Binding Protein Antigen Binding	Four-way Junction DNA Binding Bubble DNA Binding Lipopolysaccharide Binding Phosphatidylserine Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Cytokine Activity Integrin Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Lyase Activity C-X-C Chemokine Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding RAGE Receptor Binding DNA Polymerase Binding Repressing Transcription Factor Binding Supercoiled DNA Binding
	Biological Process	Platelet Degranulation Proteolysis Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Interaction With Symbiont Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Negative Regulation Of Transcription By RNA Polymerase II Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Topological Change Apoptotic DNA Fragmentation DNA Recombination Chromatin Remodeling Chromatin Silencing Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Autophagy Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Signaling Receptor Activity Positive Regulation Of Autophagy Viral Process Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Neuron Projection Development Regulation Of Restriction Endodeoxyribonuclease Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Developmental Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of Interleukin-1 Beta Secretion Positive Chemotaxis DNA Ligation Involved In DNA Repair Positive Regulation Of DNA Ligation Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Neutrophil Clearance Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interferon-alpha Secretion Positive Regulation Of Vascular Endothelial Cell Proliferation Tumor Necrosis Factor Secretion Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Dendritic Cell Differentiation
Pathways		Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Dissolution of Fibrin Clot	Apoptosis induced DNA fragmentation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Desmoteplase Aprotinin Copper Gabexate	Ethyl pyruvate
Diseases		Inherited thrombophilia
GWAS		Aging ( 22773346) Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Childhood ear infection ( 27182965 28928442) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) End stage renal disease x APOL1 genotype interaction ( 29885931) Giant cell arteritis ( 28041642) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 26377243) Lp (a) levels ( 21900290) Myocardial infarction ( 26343387) Plasma plasminogen levels ( 25208887) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		60 interacting genes: ACTB AMOT ANXA2 APOH ATP5F1B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1	94 interacting genes: ACBD3 AGER AGTRAP AR ATOH1 C1QBP C3 CASP3 CCAR1 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DNM2 DNMT1 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MECP2 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 SIX5 SOX18 SPINT1 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBE2I UNC119 ZFP36 ZNF24 ZNF428
Entrez ID		5340	3146
HPRD ID		01417	01228
Ensembl ID		ENSG00000122194	ENSG00000189403
Uniprot IDs		P00747 Q5TEH5	A0A024RDR0 P09429
PDB IDs		1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4CIK 4DCB 4DUR 4DUU 5HPG 5UGD 5UGG 6D3X 6D3Y 6D3Z 6D40 6OG4 6OQJ 6OQK	2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM
Enriched GO Terms of Interacting Partners?
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