PLCD1 and TGM2

Number of citations of the paper that reports this interaction (PubMedID 10518533)
24

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		PLCD1	TGM2
Description		phospholipase C delta 1	transglutaminase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cell Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Cell Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Intrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Calcium Ion Binding Phosphatidylinositol-4,5-bisphosphate Binding GTPase Activating Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Phospholipid Metabolic Process Lipid Catabolic Process Inositol Trisphosphate Biosynthetic Process Regulation Of Cell Proliferation Inositol Phosphate Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Labyrinthine Layer Blood Vessel Development	Blood Vessel Remodeling Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs		1D-myo-inositol 1,4,5-trisphosphate Inositol 2,4,5-trisphosphate	Guanosine-5'-Diphosphate
Diseases
GWAS
Interacting Genes		9 interacting genes: APP CALM1 GAP43 KPNB1 PAXIP1 RALA RALB TGM2 USP54	59 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		5333	7052
HPRD ID		09073	01825
Ensembl ID		ENSG00000187091	ENSG00000198959
Uniprot IDs		A0A384MR47 A8K8F9 P51178	B4DIT7 B4DTN7 P21980 V9HWG3
PDB IDs			1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P
Enriched GO Terms of Interacting Partners?
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