PITPNA and DCC

Number of citations of the paper that reports this interaction (PubMedID 16244667)
34

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PITPNA	DCC
Description		phosphatidylinositol transfer protein alpha	DCC netrin 1 receptor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytosol Plasma Membrane Axon Schaffer Collateral - CA1 Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Phosphatidylcholine Transporter Activity Phosphatidylinositol Transporter Activity Phosphatidylcholine Binding Phosphatidylinositol Binding Phosphatidylglycerol Binding	Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding
	Biological Process	Lipid Metabolic Process Axonogenesis Visual Perception Phospholipid Transport Interleukin-12-mediated Signaling Pathway	Neuron Migration Apoptotic Process Axonogenesis Axon Guidance Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Collateral Sprouting Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Neuron Death Negative Regulation Of Netrin-activated Signaling Pathway Negative Regulation Of Dendrite Development
Pathways		Role of second messengers in netrin-1 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs		1,2-diacyl-sn-glycero-3-phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
Diseases			Colorectal cancer Gastric cancer Cancer of the anal canal
GWAS		Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Age at first sexual intercourse ( 27089180) Alcoholism (alcohol use disorder factor score) ( 21529783) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Benign prostatic hyperplasia ( 30988330) Body mass index ( 28892062) Body mass index (ever vs never smoking interaction) ( 23192594) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Chronic back pain ( 30261039) Coenzyme Q10 levels ( 27149984) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 27089181 29700475) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling miserable ( 29500382) Gallbladder cancer ( 22318345) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glucose homeostasis traits ( 25524916) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30591961) Lung function (FVC) ( 30061609 30804560) Mood instability ( 31168069 29187730) Mosquito bite size ( 28199695) Multisite chronic pain ( 31194737) Neurociticism ( 29500382) Nickel levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Putamen volume ( 29147026) Response to exercise (triglyceride level interaction) ( 26491034) Response to fenofibrate (total cholesterol levels) ( 27002377) Response to mTOR inhibitor (everolimus) ( 24009623) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Short-term memory (digit-span task) ( 30741946) Smoking behaviour (cigarettes smoked per day) ( 27393504) Smoking status (ever vs never smokers) ( 30643258) Subcortical brain region volumes ( 25607358) Survival in colorectal cancer (distant metastatic) ( 26586795)
Interacting Genes		9 interacting genes: CSNK2B DCC EGFR NEO1 PABPC1 PI4KA PIK3C3 PLCG1 SCP2	15 interacting genes: ADORA2B APPL1 AR BARD1 CASP3 CASP9 MAPK3 MAZ NCK1 NTN1 PITPNA PTK2 RPL5 SIAH1 SIAH2
Entrez ID		5306	1630
HPRD ID		02548	00391
Ensembl ID		ENSG00000174238	ENSG00000187323
Uniprot IDs		Q00169 V9HWC5	P43146 Q49AK4
PDB IDs		1UW5	2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83
Enriched GO Terms of Interacting Partners?
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