SERPINA1 and MMP11

Number of citations of the paper that reports this interaction (PubMedID 7523394)
33

Data Source:
HPRD (in vivo, in vitro)

		SERPINA1	MMP11
Description		serpin family A member 1	matrix metallopeptidase 11
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process COPII Vesicle Coating	Proteolysis Multicellular Organism Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Negative Regulation Of Fat Cell Differentiation Basement Membrane Organization
Pathways		Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation	Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
Drugs		Zinc 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Beta-Mercaptoethanol Recombinant alpha 1-antitrypsin Copper	Marimastat 1-Benzyloxycarbonylamino-2-Phenyl-Ethyl)-{2-[1-Carbamoyl-2-(1h-Indol-3-Yl)-Ethylcarbamoyl]-5-Phenyl-Pentyl}-Phosphinic Acid
Diseases		Alpha-1-antitrypsin (A1AT) deficiency
GWAS		Alanine transaminase levels ( 28887542) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 22808956) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 30072576 29875488 28240269 23696881) Breast size ( 27182965) C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Gallstone disease ( 30504769) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Height ( 28552196 29782485) Large artery stroke ( 28265093) LDL cholesterol ( 30275531) Manganese levels ( 26025379) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Platelet count ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Serum alkaline phosphatase levels ( 31666285) Serum alpha-fetoprotein levels ( 31666285) Sucrose liking ( 31005972) Total cholesterol levels ( 30275531)
Interacting Genes		28 interacting genes: ADAMTS4 ATP5F1C CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE FBLN5 GLP1R GSDMB KLK3 KLK5 LAMTOR5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SMAD4 VKORC1	2 interacting genes: PRPF40A SERPINA1
Entrez ID		5265	4320
HPRD ID		02463	01705
Ensembl ID		ENSG00000197249	ENSG00000099953
Uniprot IDs		E9KL23 P01009	B3KQS8 P24347
PDB IDs		1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 4PYW 5IO1 5NBU 5NBV 6HX4 6I4V 6I7U 7API 8API 9API
Enriched GO Terms of Interacting Partners?
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