PHEX and FGF23

Number of citations of the paper that reports this interaction (PubMedID 11409890)
63

Data Source:
HPRD (in vitro)

		PHEX	FGF23
Description		phosphate regulating endopeptidase homolog X-linked	fibroblast growth factor 23
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Cell Endoplasmic Reticulum Lumen Golgi Lumen
	Molecular Function	Metalloendopeptidase Activity Zinc Ion Binding	Type 1 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Skeletal System Development Cellular Protein Modification Process Proteolysis Cell-cell Signaling Organophosphate Metabolic Process Bone Mineralization Lung Development Odontogenesis Bone Development Response To Growth Hormone Cellular Response To Vitamin D Cellular Response To Parathyroid Hormone Stimulus Response To Sodium Phosphate Response To Insulin-like Growth Factor Stimulus	MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphate Transport Positive Regulation Of Vitamin D 24-hydroxylase Activity Cell Differentiation Negative Regulation Of Bone Mineralization Cellular Phosphate Ion Homeostasis Response To Magnesium Ion Vitamin D Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Cellular Response To Leptin Stimulus Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Hormone Secretion Positive Regulation Of Protein Kinase B Signaling Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Vitamin D Cellular Response To Interleukin-6 Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Response To Sodium Phosphate
Pathways			PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR1c and Klotho ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer Post-translational protein phosphorylation
Drugs
Diseases		Hypophosphatemic rickets; X-Linked dominant hypophosphatemia (XLH); Autosomal dominant hypophosphatemic rickets (ADHR); Autosomal recessive hypophosphatemic rickets (ARHR); Hereditary hypophophatemic rickets with hypercalciuria (HHRH)	Hypophosphatemic rickets; X-Linked dominant hypophosphatemia (XLH); Autosomal dominant hypophosphatemic rickets (ADHR); Autosomal recessive hypophosphatemic rickets (ARHR); Hereditary hypophophatemic rickets with hypercalciuria (HHRH)
GWAS		Anger ( 24489884) F-cell distribution in sickle cell anaemia ( 21326311) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Phosphorus levels ( 29403010) Tourette syndrome ( 22889924)	Colorectal cancer ( 23263487) Migraine ( 27182965) Phosphorus levels ( 29403010 20558539)
Interacting Genes		1 interacting genes: FGF23	4 interacting genes: ERC1 FGFR2 FGFR3 PHEX
Entrez ID		5251	8074
HPRD ID		02387	05648
Ensembl ID		ENSG00000102174	ENSG00000118972
Uniprot IDs		B4DNS0 B4DWG8 P78562	Q9GZV9
PDB IDs			2P39 5W21
Enriched GO Terms of Interacting Partners?
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