Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
PHB and RB1
Number of citations of the paper that reports this interaction (PubMedID
10376528
)
69
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
PHB
RB1
Description
prohibitin
RB transcriptional corepressor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Early Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Membrane
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Spindle
Cyclin/CDK Positive Transcription Elongation Factor Complex
SWI/SNF Complex
PML Body
Rb-E2F Complex
Molecular Function
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Complement Component C3a Binding
Complement Component C3b Binding
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Proteinase Activated Receptor Binding
Histone Deacetylase Binding
Transcription Regulatory Region DNA Binding
Proximal Promoter Sequence-specific DNA Binding
RNA Polymerase II Regulatory Region DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
DNA Binding
DNA-binding Transcription Factor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Androgen Receptor Binding
Phosphoprotein Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Regulation Of Transcription, DNA-templated
Mitochondrial Calcium Ion Transmembrane Transport
Mitochondrion Organization
Signal Transduction
Negative Regulation Of Cell Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Cell Death
Negative Regulation Of Transcription By Competitive Promoter Binding
Histone Deacetylation
Negative Regulation Of Cell Growth
Negative Regulation Of Protein Catabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Complement Activation
Protein Stabilization
Progesterone Receptor Signaling Pathway
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interleukin-6
DNA Biosynthetic Process
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Tissue Homeostasis
Aortic Valve Morphogenesis
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Cell Cycle Arrest
Mitotic Cell Cycle Checkpoint
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Viral Process
Cell Differentiation
Neuron Differentiation
Negative Regulation Of Cell Growth
Androgen Receptor Signaling Pathway
Sister Chromatid Biorientation
Neuron Projection Development
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Cell Division
Neuron Apoptotic Process
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Cohesin Loading
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Tau-protein Kinase Activity
Positive Regulation Of Extracellular Matrix Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
RAF activation
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Processing of SMDT1
Signaling downstream of RAS mutants
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Drugs
Insulin Human
Insulin Pork
Diseases
Bladder cancer
Small cell lung cancer
Glioma
Osteosarcoma
Breast cancer
Esophageal cancer
Hepatocellular carcinoma
Chronic myeloid leukemia (CML)
GWAS
Asthma (
30929738
29273806
)
Asthma (adult onset) (
30929738
)
Asthma (childhood onset) (
31036433
30929738
)
Cancer (
29299148
)
Coronary artery disease (
29212778
)
Diastolic blood pressure (
19430483
27841878
)
Lower body strength (
27325353
)
Metabolite levels (
23823483
)
Prostate cancer (
23535732
)
Restricted and repetitive behaviours in autism spectrum disorder (
28533516
)
Systolic blood pressure (
27841878
30578418
)
Birth weight (
31043758
27680694
)
Chronic kidney disease (
26420894
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
23 interacting genes:
ANXA2
BCAS3
CASC3
CCL5
COX6C
E2F1
ESR1
HDAC1
LONRF3
MAP3K10
MCM2
NCOR1
RAF1
RB1
RBL1
RBL2
SIN3A
SMARCA2
SMARCA4
ST14
SUMO4
TP53
XPO1
173 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX1
CBX4
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CREG1
CTBP1
CUX1
DGKZ
DNMT1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FOS
FRK
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KMT5C
L3MBTL1
LIN54
LIN9
LMNA
MAPK1
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TP53
TRAP1
TRIM27
TRIP11
UBE2I
UBTF
USP4
USP7
VDR
ZBTB16
Entrez ID
5245
5925
HPRD ID
01454
01574
Ensembl ID
ENSG00000167085
ENSG00000139687
Uniprot IDs
A8K401
P35232
Q53FV0
A0A024RDV3
P06400
PDB IDs
1LU7
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?