ABCB4 and PIGY

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ABCB4	PIGY
Description		ATP binding cassette subfamily B member 4	phosphatidylinositol glycan anchor biosynthesis class Y
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Integral Component Of Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Phospholipid Transporter Activity ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Phosphatidylcholine-translocating ATPase Activity Ceramide-translocating ATPase Activity	Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane
Pathways		PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Alanine transaminase levels ( 29403010) Epithelial ovarian cancer ( 25134534) Gallbladder cancer ( 28274756) Gallstone disease ( 30504769) LDL cholesterol ( 30275531) Total cholesterol levels ( 30275531)	Bipolar disorder ( 22925353) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: HAX1 PIGY PRKAR2B TESK1	3 interacting genes: ABCB4 FBXO7 PIGA
Entrez ID		5244	84992
HPRD ID		01371	17492
Ensembl ID		ENSG00000005471	ENSG00000255072
Uniprot IDs		P21439	Q3MUY2
PDB IDs
Enriched GO Terms of Interacting Partners?
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