PECAM1 and YES1

Number of citations of the paper that reports this interaction (PubMedID 10858437)
17

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PECAM1	YES1
Description		platelet and endothelial cell adhesion molecule 1	YES proto-oncogene 1, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Integral Component Of Membrane Smooth Muscle Contractile Fiber Secretory Granule Membrane Platelet Alpha Granule Membrane Protein-containing Complex Cell-cell Contact Zone Membrane Raft Extracellular Exosome	Golgi Apparatus Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Protein Binding Protein Homodimerization Activity	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Positive Regulation Of Protein Phosphorylation Platelet Degranulation Phagocytosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Cell Recognition Extracellular Matrix Organization Positive Regulation Of Cell Migration Monocyte Extravasation Wound Healing Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Neutrophil Degranulation Endothelial Cell Migration Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Diapedesis Establishment Of Endothelial Barrier Bicellular Tight Junction Assembly Glomerular Endothelium Development Neutrophil Extravasation Endothelial Cell-matrix Adhesion Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Glucose Transmembrane Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Regulation Of Vascular Permeability Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation	Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Dasatinib
Diseases
GWAS		Coronary artery disease ( 29212778) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878)	Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 30224653 29403010 30487518 30578418)
Interacting Genes		22 interacting genes: CD38 CSK CTNNB1 DSP EFNB2 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1	54 interacting genes: ADAM12 ADAM15 BECN1 C1orf94 CBL CD2AP CD36 CD46 CDH1 CDKN1B CSF1R DLG4 DOK1 DVL2 EPHB2 FASLG FGFR1 FLT1 FUNDC1 FXR2 GP6 ITGB4 JAK2 KDR KHDRBS1 KIT MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PTEN PTK2 PTPRE RASA1 RPL10 SKAP2 SLC9A3R1 SOCS3 SPRR2A SSBP3 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRPV4 TYRO3 ZBTB8A ZNF512B
Entrez ID		5175	7525
HPRD ID		01425	01285
Ensembl ID		ENSG00000261371	ENSG00000176105
Uniprot IDs		P16284	P07947
PDB IDs		2KY5 5C14 5GNI	2HDA
Enriched GO Terms of Interacting Partners?
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