WWOX and SEC23IP

Number of citations of the paper that reports this interaction (PubMedID 30619736)
1

Data Source:
BioGRID (pull down)

		WWOX	SEC23IP
Description		WW domain containing oxidoreductase	SEC23 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Factor Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane COPII-coated ER To Golgi Transport Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding	RNA Binding Phospholipase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Oxidation-reduction Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Golgi Organization COPII Vesicle Coating
Pathways		Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors	COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa ( 23568457) Bipolar disorder (body mass index interaction) ( 24322204) Brain volume in infants (white matter) ( 28763065) Cardiac structure and function ( 19584346) Clozapine-induced cytotoxicity ( 25656473) Colorectal cancer ( 30529582 29228715) Daytime sleep phenotypes ( 27126917) Diffusing capacity of carbon monoxide ( 30694715) Early-onset Parkinson's disease ( 28256260) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Familial squamous cell lung carcinoma ( 29924316) FEV1 ( 30804560) Hip shape (DXA scan) ( 30320955) Idiopathic dilated cardiomyopathy ( 29495422) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Metabolite levels ( 23823483) Metabolite levels (5-HIAA) ( 23319000) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Obesity ( 21552555) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Radiation response ( 20923822) Response to amphetamines ( 22952603) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum thyroid-stimulating hormone levels ( 25436638) Serum uric acid levels in response to allopurinol in gout ( 25676789) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Systemic juvenile idiopathic arthritis ( 27927641) Type 2 diabetes ( 22158537) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Cerebrospinal fluid clusterin levels ( 26545630) Menarche (age at onset) ( 25231870)
Interacting Genes		25 interacting genes: APBB2 CLNK CPSF2 CPSF7 ERBB4 EZR FIP1L1 HNRNPK HYAL2 LATS1 MAPK8 NUDT21 SCAMP3 SEC23IP SF3B3 SMAD4 SRC TCERG1 TFAP2C TNK2 TP53 TP73 UBB WDR33 WIPF2	5 interacting genes: HSPB11 PCNA POLD4 SSC5D WWOX
Entrez ID		51741	11196
HPRD ID		05501	07152
Ensembl ID		ENSG00000186153	ENSG00000107651
Uniprot IDs		A0A411HBC7 Q9NZC7	Q9Y6Y8
PDB IDs		1WMV
Enriched GO Terms of Interacting Partners?
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