PDHB and PDHA2

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		PDHB	PDHA2
Description		pyruvate dehydrogenase E1 subunit beta	pyruvate dehydrogenase E1 subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity	Pyruvate Dehydrogenase (acetyl-transferring) Activity Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		Pyruvic acid NADH	NADH
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) IgG levels ( 28628107) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) vWF levels ( 30586737)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Metabolite levels ( 23823483) Triacylglyceride levels ( 31551469)
Interacting Genes		16 interacting genes: AKT1 ANXA7 CDKN1A FCER1A GNB2 GRB7 HSD17B10 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RCC1 TRIM63 TSC22D1	1 interacting genes: PDHB
Entrez ID		5162	5161
HPRD ID		01530	01531
Ensembl ID		ENSG00000168291	ENSG00000163114
Uniprot IDs		A0A384MDR8 P11177	P29803
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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