MED15 and MED25

Number of citations of the paper that reports this interaction (PubMedID 14983011)
61

Data Source:
HPRD (in vivo)

		MED15	MED25
Description		mediator complex subunit 15	mediator complex subunit 25
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane Mediator Complex	Nucleoplasm Mediator Complex Nuclear Transcription Factor Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Stem Cell Population Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Lung function (FEV1/FVC) ( 30061609)	Blood trace element (Se levels) ( 23720494)
Interacting Genes		12 interacting genes: ATP5F1C ATXN1 CTDP1 FHL3 MED25 MLLT6 PLSCR1 RELA SMAD2 SMAD3 TRIM11 UBC	14 interacting genes: CDK8 CREBBP CTDP1 HCFC1 MED1 MED15 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA
Entrez ID		51586	81857
HPRD ID		12117	14380
Ensembl ID		ENSG00000099917	ENSG00000104973
Uniprot IDs		B7Z2H7 G3V1P5 Q6PKB8 Q96RN5	M0QZQ2 Q71SY5
PDB IDs		2GUT	2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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