PEX5L and RAF1

Number of citations of the paper that reports this interaction (PubMedID 15302887)
19

Data Source:
HPRD (in vitro, in vivo)

		PEX5L	RAF1
Description		peroxisomal biogenesis factor 5 like	Raf-1 proto-oncogene, serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisomal Membrane Cytosol Receptor Complex	Cell Cytoplasm Mitochondrion Mitochondrial Outer Membrane Golgi Apparatus Cytosol Plasma Membrane Nuclear Speck Pseudopodium
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Small GTPase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Adenylate Cyclase Binding Adenylate Cyclase Activator Activity Enzyme Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Protein Import Into Peroxisome Matrix, Docking Regulation Of CAMP-mediated Signaling	MAPK Cascade Activation Of MAPKK Activity Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Apoptotic Process Signal Transduction Activation Of Adenylate Cyclase Activity Heart Development Negative Regulation Of Cell Proliferation Cell Differentiation Platelet Activation Thyroid Gland Development Negative Regulation Of Protein Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Somatic Stem Cell Population Maintenance Regulation Of Rho Protein Signal Transduction Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Muscle Stretch Wound Healing Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intermediate Filament Cytoskeleton Organization Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Thymus Development Face Development Death-inducing Signaling Complex Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Motility
Pathways			Stimuli-sensing channels Rap1 signalling GP1b-IX-V activation signalling CD209 (DC-SIGN) signaling RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			Sorafenib LErafAON XL281 iCo-007 Regorafenib Dabrafenib
Diseases
GWAS		Bipolar disorder ( 31043756) Blood metabolite levels ( 24816252) Glucose homeostasis traits ( 25524916) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 21490949)	Cardiac hypertrophy ( 21348951) Cholesterol, total ( 24097068 20686565) Total cholesterol levels ( 28334899) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: PEX7 RAF1	160 interacting genes: ABCB5 ADCY6 AGTR1 AKT1 AR ARNT ARRB2 BAD BAG1 BCL2 BCL2L1 BCL6 BECN1 BIRC2 BIRC3 BRAF CASZ1 CBLC CCND2 CCT3 CD44 CDC25A CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFLAR CNKSR1 COPS3 COPS7A CPS1 DCAF8 DMPK EFEMP1 EGFR EPHA2 ERBB2 ERBIN FGFR4 FYCO1 FYN GLIS2 GNB2 GNG4 GRB10 GRM1 HERC1 HGF HRAS HSP90AA1 HSPA4 HSPA8 IL2RB INSR INTS10 JAK1 JAK2 KEAP1 KRAS KRT18 KRT8 KSR1 KSR2 LATS2 LCK LOX LRPAP1 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MAP2K6 MAP3K1 MAP3K5 MAPK1 MAPK3 MAPK7 MAPK8 MAPK8IP3 MET MRAS MRC2 MYBPC1 MYC NEDD4 NF1 NF2 NPLOC4 NR3C1 NRAS NUDT14 OIP5 PACSIN3 PAK1 PAK2 PAK3 PBK PDGFRA PDGFRB PDLIM2 PEBP1 PEBP4 PEX5L PHB PHKA2 PIN1 PKM PPP1CC PPP2CB PRKAA1 PRKACA PRKAR1A PRKCA PRKCD PRKCE PRKCZ PRKG1 PRPF6 PURA RANBP9 RAP1A RAP2A RASD2 RASSF1 RB1 RBBP8 RBL2 RFXANK RHEB RRAS RRAS2 RSU1 SFN SHOC2 SPRY2 SPRY4 SRC STK26 STK3 STUB1 TBXA2R TEAD2 TERT TIMM50 TMEM70 TSC22D3 UBE2D2 UBE2L3 VAV1 VDAC1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1
Entrez ID		51555	5894
HPRD ID		11425	01265
Ensembl ID		ENSG00000114757	ENSG00000132155
Uniprot IDs		Q8IYB4	A0A0S2Z4L5 L7RRS6 P04049
PDB IDs			1C1Y 1FAQ 1FAR 1GUA 1RFA 3CU8 3IQJ 3IQU 3IQV 3KUC 3KUD 3NKX 3O8I 3OMV 4FJ3 4G0N 4G3X 4IEA 4IHL
Enriched GO Terms of Interacting Partners?
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