GSKIP and EXT2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GSKIP	EXT2
Description		GSK3B interacting protein	exostosin glycosyltransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity, Transferring Glycosyl Groups Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Ossification Mesoderm Formation Glycosaminoglycan Biosynthetic Process Protein Glycosylation Signal Transduction Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Cell Differentiation Cellular Polysaccharide Biosynthetic Process
Pathways			HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Drugs
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses Multiple exostoses
GWAS		Conotruncal heart defects (inherited effects) ( 28468790)	Height ( 28552196)
Interacting Genes		3 interacting genes: EXT2 GSK3A PEX19	10 interacting genes: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SLC22A2 SMN1 TK1 TRAP1
Entrez ID		51527	2132
HPRD ID		16601	00599
Ensembl ID		ENSG00000100744	ENSG00000151348
Uniprot IDs		A0A024R6P6 Q9P0R6	D3DR24 Q93063
PDB IDs		1SGO
Enriched GO Terms of Interacting Partners?
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