PRKAG2 and PRKAB2

Number of citations of the paper that reports this interaction (PubMedID 10698692)
166

Data Source:
HPRD (two hybrid)

		PRKAG2	PRKAB2
Description		protein kinase AMP-activated non-catalytic subunit gamma 2	protein kinase AMP-activated non-catalytic subunit beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytosol Nucleotide-activated Protein Kinase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Inhibitor Activity ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Binding Protein Kinase Activator Activity ADP Binding	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Glycolytic Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Fatty Acid Biosynthetic Process ATP Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Positive Regulation Of Peptidyl-threonine Phosphorylation Sterol Biosynthetic Process Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Metabolic Process Activation Of Protein Kinase Activity Intracellular Signal Transduction Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Protein Kinase Activity Regulation Of Fatty Acid Oxidation Regulation Of Glucose Import Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of CAMP-dependent Protein Kinase Activity	Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Acetylsalicylic acid	Adenosine monophosphate Acetylsalicylic acid
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Bipolar disorder (age of onset and psychotic symptoms) ( 21305692) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Gut microbiota (beta diversity) ( 27723756) Hematocrit ( 27863252 28017375 19862010) Hemoglobin ( 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) Intraocular pressure ( 29785010 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels (small molecules and protein measures) ( 27005778) Pulse pressure ( 27841878 30578418) Red blood cell count ( 28453575 27863252) Red blood cell traits ( 23222517) Systolic blood pressure ( 27841878 27618447 30578418) Urate levels ( 31578528 23263486) Urea levels ( 31015462 28270201)
Interacting Genes		6 interacting genes: CHPF2 DAPK1 MFHAS1 PRKAB1 PRKAB2 PRKAG1	74 interacting genes: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FDX1 FLNC GATA1 GATAD2B GET4 GOLGA2 GRN IHO1 IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PNMA1 PRDM14 PRKAA1 PRKAG1 PRKAG2 PSME3 PYGM RACK1 RBPMS REL RHEBL1 RIMBP3 SPRY2 SSX2IP STX11 STX19 TADA2A TASOR2 TCF4 TLE5 TP53 TP53BP2 TRAF1 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32
Entrez ID		51422	5565
HPRD ID		04119	04117
Ensembl ID		ENSG00000106617	ENSG00000131791
Uniprot IDs		A0A090N8Q6 A0A384MDZ2 A0A494C068 A0A494C1K7 B7Z6X8 E9PGP6 Q9UGJ0	O43741
PDB IDs			2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?